“Stealth” tumors
نویسندگان
چکیده
Breast cancers (BCs) comprise heterogeneous subtypes of various prognoses. An active anti-tumor immune profile usually correlated with a better survival. Two current major challenges of BC research are to understand the inter-relations between BC and anti-tumor immunity, and to identify candidates whose targeting would contribute to enhance anti-tumor efficiency.
منابع مشابه
Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release.
Stealth liposomes can be used to extend the blood circulation time of encapsulated therapeutics. Inclusion of 2 molar % porphyrin-phospholipid (PoP) imparted optimal near infrared (NIR) light-triggered release of doxorubicin (Dox) from conventional sterically stabilized stealth liposomes. The type and amount of PoP affected drug loading, serum stability and drug release induced by NIR light. Ch...
متن کاملEradication of interleukin 5-transfected J558L plasmacytomas in mice by hydrogen peroxide-generating Stealth liposomes.
Certain human tumors are extensively infiltrated by eosinophils and contain extracellular deposits of eosinophil peroxidase, which uses hydrogen peroxide as a substrate to produce highly toxic hypohalous acids. We hypothesized that J558L HI, an interleukin 5-transfected murine plasmacytoma that is infiltrated by numerous degranulating eosinophils, would be especially sensitive to killing by hyd...
متن کاملThe challenge of liposomes in gene therapy
Recently , l iposomes have gained a special interest as gene delivery systems: over 30 human clinical trials for gene del ivery using cationic l iposomes have been approved; al l these del ivery methods use intratumoral, subcutaneous and other local delivery but not systemic delivery due to the toxicity of cat ionic l ipids . Stealth l iposomes (coated with polyethyleneglycol to camouflage the ...
متن کاملInterference with pulse oximetry by the Stealth Station™ Image Guidance System
Background A pulse oximeter is one of the most important monitors to save patients undergoing anesthesia and monitored sedation. The authors report a case of orthopedic surgery, in which interference of pulse oximetry occurred when using a Stealth Station™ navigation system (Medtronic Sofamor Danek, Memphis, TN). Applying a black plastic shield (Masimo Ambient Shield: Masimo Corporation, Irvine...
متن کاملEPO is a heme-enzyme that catalyzes the production of cytotoxic hypohalous acids from hydrogen peroxide and halides or pseudoha
Certain human tumors are extensively infiltrated by eosinophils and contain extracellular deposits of eosinophil peroxidase, which uses hydro gen peroxide as a substrate to produce highly toxic hypohalous acids. We hypothesized that J5SSL HI, an interieukin 5-transfected murine plasma cytoma that is infiltrated by numerous degranulating eosinophils, would be especially sensitive to killing by h...
متن کامل